2-Methylquinolin-7-amine → N-(2-Methylquinolin-7-yl)-4-(1-pyrazolyl)benzamide

HRID 494251Notes

Reaction equation

HRID 494251 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[CH:4][CH:3]=1.[N:13]1([C:18]2[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=2)[CH:17]=[CH:16][CH:15]=[N:14]1>>[CH3:12][C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][C:2]([NH:1][C:22](=[O:23])[C:21]3[CH:20]=[CH:19][C:18]([N:13]4[CH:17]=[CH:16][CH:15]=[N:14]4)=[CH:26][CH:25]=3)=[CH:3][CH:4]=2)[N:9]=1

Participants

3

Reactant 2

HCID 4596552-Methylquinolin-7-amineHCID 7365274-(1H-pyrazol-1-yl)benzoic acid

Product 1

HCID 57682723N-(2-Methylquinolin-7-yl)-4-(1-pyrazolyl)benzamide

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-amino-2-methylquinoline (D66) (33 mg, 0.21 mmol) and 4-(1-pyrazolyl)benzoic acid (47 mg, 0.25 mmol) as an off-white solid. MS (ES): MH+ 329, M-H+ 327.

Sources & evidence

ORD record
ord-afdb3135bbc44f45ac0653a31255d9bf
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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