7-Aminoquinoline → HCID 57682663, compound

HRID 494255Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][N:13]([CH3:32])[S:14]([C:17]1[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][C:26]([C:29](O)=[O:30])=[CH:25][CH:24]=2)[CH:20]=[CH:21][CH:22]=1)(=[O:16])=[O:15]>>[CH3:12][N:13]([CH3:32])[S:14]([C:17]1[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([NH:1][C:2]3[CH:11]=[C:10]4[C:5]([CH:6]=[CH:7][CH:8]=[N:9]4)=[CH:4][CH:3]=3)=[O:30])=[CH:25][CH:24]=2)[CH:20]=[CH:21][CH:22]=1)(=[O:15])=[O:16]

Participants

Reactant 2

HCID 113777-Aminoquinoline

HCID 53218478HCID 53218478, compound

Product 1

HCID 57682663HCID 57682663, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (18 mg, 0.13 mmol) and 3′-dimethylsulfamoyl-1,1′-biphenyl-4-carboxylic acid (D68) (45 mg, 0.15 mmol) as a yellow oil. MS(ES): MH+ 432, M-H+ 430

Sources & evidence

ORD record: ord-f5b2fce97bcb47c6a06056bc02174b7b
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538121B2

Reaction notes

Loading…