7-Aminoquinoline → HCID 57682739, compound

HRID 494256Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH:12]1([C:18]2[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>>[CH:12]1([C:18]2[CH:19]=[CH:20][C:21]([C:22]([NH:1][C:2]3[CH:11]=[C:10]4[C:5]([CH:6]=[CH:7][CH:8]=[N:9]4)=[CH:4][CH:3]=3)=[O:23])=[CH:25][CH:26]=2)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1

Participants

Reactant 2

HCID 113777-Aminoquinoline

HCID 883374-Cyclohexylbenzoic acid

Product 1

HCID 57682739HCID 57682739, compound

Procedure

Using the procedure outlined in Example 45, the title compound was prepared from 7-aminoquinoline (D55) (30 mg, 21 mmol) and 4-cyclohexylbenzoic acid (51 mg, 0.25 mmol) as a yellow solid. MS(ES): MH+ 331, M-H+ 329

Sources & evidence

ORD record: ord-284f2c4a2ec947c5b9580dd215bb874c
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538121B2

Reaction notes

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