7-Aminoquinoline → HCID 57682672, compound

HRID 494259Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH2:12]([C:14]1[N:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:15]=1[C:16](O)=[O:17])C>>[CH3:12][C:14]1[N:22]=[C:21]([C:23]([F:26])([F:24])[F:25])[CH:20]=[CH:19][C:15]=1[C:16]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1)=[O:17]

Participants

Reactant 2

HCID 113777-Aminoquinoline

HCID 69049605HCID 69049605, compound

Product 1

HCID 57682672HCID 57682672, compound

Procedure

Using the procedure outlined in Example 45, the title compound was prepared from 7-aminoquinoline (D55) (30 mg, 21 mmol) and 2-ethyl -6-trifluoromethylnicotinic acid (51 mg, 0.25 mmol) as a yellow solid. MS(ES): MH+ 332, M-H+ 330

Sources & evidence

ORD record: ord-ac9288f7cfe34363a8157cea48e28296
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538121B2

Reaction notes

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