7-Aminoquinoline → 2-Methyl-6-phenyl-N-quinolin-7-yl-nicotinamide

HRID 494272Notes

Reaction equation

HRID 494272 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][C:13]1[N:21]=[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:19]=[CH:18][C:14]=1[C:15](O)=[O:16]>>[CH3:12][C:13]1[N:21]=[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:19]=[CH:18][C:14]=1[C:15]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1)=[O:16]

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 8229602-methyl-6-phenylnicotinic acid

Product 1

HCID 445788932-Methyl-6-phenyl-N-quinolin-7-yl-nicotinamide

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (28 mg, 0.9 mmol) and 2-methyl-6-phenylnicotinic acid (D23) (50 mg, 0.24 mmol) as a yellow solid. MS(ES): MH+ 340, M-H+ 338

Sources & evidence

ORD record
ord-5f97eb884cc142839d008364e098113d
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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