7-Aminoquinoline → HCID 57682738, compound

HRID 494274Notes

Reaction equation

[F:1][C:2]([F:19])([F:18])[C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=O)[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=1.[NH2:20][C:21]1[CH:30]=[C:29]2[C:24]([CH:25]=[CH:26][CH:27]=[N:28]2)=[CH:23][CH:22]=1>>[N:28]1[C:29]2[C:24](=[CH:23][CH:22]=[C:21]([NH:20][C:15]([CH:12]3[CH2:11][CH2:10][N:9]([C:7]4[CH:6]=[CH:5][CH:4]=[C:3]([C:2]([F:1])([F:19])[F:18])[N:8]=4)[CH2:14][CH2:13]3)=[O:17])[CH:30]=2)[CH:25]=[CH:26][CH:27]=1

Participants

Reactant 2

HCID 113777-Aminoquinoline

HCID 26986141HCID 26986141, compound

Product 1

HCID 57682738HCID 57682738, compound

Procedure

Using the procedure outlined in Example 107, the title compound was prepared from 1-(6-trifluoromethylpyrid-2-yl)-piperidine-4-carboxylic acid (D102) (100 mg, 0.36 mmol) and 7-aminoquinoline (D55) (27 mg, 0.19 mmol) as an off white solid. MS(ES): MH+ 401, M-H+ 399.

Sources & evidence

ORD record: ord-a3c1ad799dbe42b8a4162bdb27f43ddd
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538121B2

Reaction notes

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