7-Aminoquinoline → HCID 57682668, compound

HRID 494276Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][N:13]([CH3:33])[CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](O)=[O:24])[CH:20]=[CH:19][C:18]=1[C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=1>>[CH3:12][N:13]([CH3:33])[CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23]([NH:1][C:2]2[CH:11]=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[N:9]3)=[CH:4][CH:3]=2)=[O:24])[CH:20]=[CH:19][C:18]=1[C:26]1[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=1

Participants

Reactant 2

HCID 113777-Aminoquinoline

HCID 69039894HCID 69039894, compound

Product 1

HCID 57682668HCID 57682668, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (20 mg, 0.14 mmol) and 2-(2-dimethylaminoethoxy)-4′-fluoro-1,1′-biphenyl-4-carboxylic acid (D79) (50 mg, 0.17 mmol) as a yellow solid. MS(ES): MH+ 430, M-H+ 428

Sources & evidence

ORD record: ord-2233f8f95a8a4a4d993e35077e3067e2
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538121B2

Reaction notes

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