7-Aminoquinoline → HCID 57682744, compound

HRID 494278Notes

Reaction equation

HRID 494278 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[Cl:12][C:13]1[C:14]([C:19]2[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=2)=[N:15][CH:16]=[CH:17][CH:18]=1>>[Cl:12][C:13]1[C:14]([C:19]2[CH:27]=[CH:26][C:22]([C:23]([NH:1][C:2]3[CH:11]=[C:10]4[C:5]([CH:6]=[CH:7][CH:8]=[N:9]4)=[CH:4][CH:3]=3)=[O:24])=[CH:21][CH:20]=2)=[N:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 221704544-(3-Chloropyridin-2-yl)benzoic acid

Product 1

HCID 57682744HCID 57682744, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (25 mg, 0.14 mmol) and 4-(3-Chloro-2-pyridyl)-benzoic acid (D84) (50 mg, 0.17 mmol) as a brown solid. MS(ES): MH+ 362/360, M-H+ 360/358.

Sources & evidence

ORD record
ord-e91784e5adc741bdb0578d5e8c555db8
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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