(1,1'-Biphenyl)-4-carboxylic acid → HCID 49741338, compound

HRID 494284Notes

Reaction equation

HRID 494284 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:13])=[CH:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[C:14]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1>>[CH3:13][C:6]1[C:5]2[C:10](=[CH:11][C:2]([NH:1][C:20]([C:17]3[CH:18]=[CH:19][C:14]([C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)=[CH:15][CH:16]=3)=[O:21])=[CH:3][CH:4]=2)[NH:9][C:8](=[O:12])[CH:7]=1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 882777-Amino-4-methyl-2-quinolinone

Product 1

HCID 49741338HCID 49741338, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-amino-4-methyl-1-H-quinolin-2-one (50 mg, 0.29 mmol) and 4-biphenylcarboxylic acid (68 mg, 0.34 mmol) as a cream solid. 1H NMR (250 MHz, DMSO) δ (ppm): 11.60 (br, 1H), 10.55 (br, 1H), 8.09 (d, 2H), 8.02 (s, 1H), 7.86 (d, 2H), 7.77 (d, 2H), 7.69 (d, 1H), 7.55 (dd, 1H), 7.52 (t, 2H), 7.43 (t, 1H), 6.29 (s, 1H), 2.41 (s, 3H).

Sources & evidence

ORD record
ord-550dbf5add5f4b88b71285b0deb4d569
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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