HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminoisoquinoline → N-Isoquinolin-5-yl-1-(5-trifluoromethylpyrid-2-yl)-piperidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminoisoquinoline | HCID 70766 | — |
| Reactant | 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid | HCID 2777788 | — |
| Product | N-Isoquinolin-5-yl-1-(5-trifluoromethylpyrid-2-yl)-piperidine-4-carboxamide | HCID 11689858 | — |
Reaction Steps
Using the procedure outlined in Example 107, the title compound was prepared from 1-(5-trifluoromethylpyrid-2-yl)-piperidine-4-carboxylic acid (D101) (100 mg, 0.36 mmol) and 5-aminoisoquinoline (27 mg, 0.19 mmol) as an off white solid. MS(ES): MH+ 401, M-H+ 399.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07538121B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-c8a4397337eb4c0da914e85db52378b8 |
| Source note | uspto-grants-2009_05 |