6-Aminoquinoline → HCID 44415653, compound

HRID 494295Notes

Reaction equation

HRID 494295 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[C:12]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:17]=[CH:16][C:15]([C:18](O)=[O:19])=[CH:14][CH:13]=1>>[N:8]1[C:9]2[C:4](=[CH:3][C:2]([NH:1][C:18]([C:15]3[CH:16]=[CH:17][C:12]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:13][CH:14]=3)=[O:19])=[CH:11][CH:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 113736-AminoquinolineHCID 66724(1,1'-Biphenyl)-4-carboxylic acid

Product 1

HCID 44415653HCID 44415653, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 6-aminoquinoline (72 mg, 0.75 mmol) and 4-biphenylcarboxylic acid (149 mg, 0.75 mmol) as a white solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 9.22 (d, 1H), 8.88 (dd, 1H), 8.52 (d, 1H), 8.33 (dd, 1H), 8.19 (d, 1H), 8.13 (d, 1H), 8.09 (d, 1H), 8.08 (m, 3H), 7.91 (d, 1H), 7.72 (dd, 1H), 7.52 (m, 3H), 7.43 (dd, 1H).

Sources & evidence

ORD record
ord-eb0001066e6b4b569181ee5b7375e29f
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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