3,4-dihydro-2H-pyran → HCID 57682961, compound

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Reaction Steps

100 g of isopropyl (1R,3S)-3-hydroxymethylcyclohexanecarboxylate and 46.2 g of dihydropyran are dissolved in 500 ml of dichloromethane and, at 0° C., 4.75 g of toluenesulfonic acid monohydrate are added. The solution is stirred overnight and then sat. sodium bicarbonate solution is added. The organic phase is separated off, diluted with MTBE and washed with sat. sodium chloride solution, dried over MgSO4 and concentrated, resulting in 140 g of isopropyl (1R,3S)-3-(tetrahydropyran-2-yloxymethyl)cyclohexanecarboxylate as brown oil.

Provenance & Evidence