Cyclopentylamine → HCID 57683025, compound

HRID 494321Notes

Reaction equation

HRID 494321 reaction equation
C1(CNC(C2NC=C(C(C3[C:16]([C:21]4[CH:26]=[CH:25][C:24](F)=CC=4)=[N:17]OC=3C)=O)C=2)=O)CC1.[F:28][C:29]1[CH:30]=[C:31]([C:37]2[C:41]([C:42]([C:44]3[CH:45]=[C:46]([C:49](=[O:54])C(Cl)(Cl)Cl)[NH:47][CH:48]=3)=[O:43])=[C:40]([CH3:55])[O:39][N:38]=2)[CH:32]=[C:33]([F:36])[C:34]=1[F:35].C1(N)CCCC1>>[CH:16]1([NH:17][C:49]([C:46]2[NH:47][CH:48]=[C:44]([C:42]([C:41]3[C:37]([C:31]4[CH:30]=[C:29]([F:28])[C:34]([F:35])=[C:33]([F:36])[CH:32]=4)=[N:38][O:39][C:40]=3[CH3:55])=[O:43])[CH:45]=2)=[O:54])[CH2:21][CH2:26][CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 2906CyclopentylamineHCID 57683109HCID 57683109, compound2×HCID 57683183HCID 57683183, compound

Product 1

HCID 57683025HCID 57683025, compound

Procedure

According to the procedure described for the synthesis of 4-(5-methyl-3-(4-fluorophenyl)-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid (cyclopropylmethyl)-amide (example 229, step 2), the title compound has been synthesized from 4-[3-(3,4,5-trifluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-2-trichloroacetyl-1H-pyrrole (intermediate 18) and cyclopentylamine (commercially available) in 49.6 yield. (m/e): 418.3 (MH+; 100%).

Sources & evidence

ORD record
ord-fae38fab5eae47288fd7951e9e8783fa
Source dataset
uspto-grants-2009_05
Patent number
US07538132B2

Reaction notes

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