HCID 16071599, compound → HCID 57683140, compound

HRID 494323Notes

Reaction equation

[CH:1]1(CNC(C2N(C)C=C(C(C3C(C4C=CC(F)=CC=4)=NOC=3C)=O)C=2)=O)CC1.[CH:29]1([NH:34][C:35]([C:37]2[NH:38][CH:39]=[C:40]([C:42]([C:44]3[C:45]([C:50]4[CH:55]=[CH:54][CH:53]=[C:52]([F:56])[CH:51]=4)=[N:46][O:47][C:48]=3[CH3:49])=[O:43])[CH:41]=2)=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30]1>>[CH:29]1([NH:34][C:35]([C:37]2[N:38]([CH3:1])[CH:39]=[C:40]([C:42]([C:44]3[C:45]([C:50]4[CH:55]=[CH:54][CH:53]=[C:52]([F:56])[CH:51]=4)=[N:46][O:47][C:48]=3[CH3:49])=[O:43])[CH:41]=2)=[O:36])[CH2:30][CH2:31][CH2:32][CH2:33]1

Participants

Reactant 2

HCID 16071599HCID 16071599, compound

HCID 57683030HCID 57683030, compound

Product 1

HCID 57683140HCID 57683140, compoundYield 27.6%

Procedure

According to the procedure described for the synthesis of 4-(5-methyl-3-(4fluorophenyl)-isoxazole-4-carbonyl)-1-methyl-pyrrole-2-carboxylic acid (cyclopropylmethyl)-amide (Example 229, step 3), the title compound was synthesized from 4-[5-methyl-3-(3-fluorophenyl)-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid cyclopentylamide (example 178) in 27.6% yield as white solid. (m/e): 396.2 (M+1; 100%).

Sources & evidence

ORD record: ord-3452765f3c89427e9311937ffaf5b894
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538132B2

Reaction notes

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