Propargylamine → HCID 57683094, compound

Participants

Reaction Steps

According to the procedure described for the synthesis of 4-(5-methyl-3-(4-fluorophenyl)-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid (cyclopropylmethyl)-amide (example 229, step 2), the title compound has been synthesized from 4-[3-(3,4-difluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-2-trichloroacetyl-1H-pyrrole (intermediate 19) and prop-2-ynylamine (commercially available) in 28.1 yield. (m/e): 370.0 (MH+; 100%).

Provenance & Evidence