HCID 57682986, compound → HCID 16071485, compound

HRID 494327Notes

Reaction equation

HRID 494327 reaction equation
C1(CNC(C2NC=C(C([C:15]3[C:16]([C:21]4[CH:26]=CC(F)=CC=4)=[N:17][O:18][C:19]=3C)=O)C=2)=O)CC1.[F:28][C:29]1[CH:30]=[C:31]([C:36]2[C:40]([C:41]([C:43]3[CH:44]=[C:45]([C:48](=[O:53])C(Cl)(Cl)Cl)[NH:46][CH:47]=3)=[O:42])=[C:39]([CH3:54])[O:38][N:37]=2)[CH:32]=[CH:33][C:34]=1[F:35]>>[O:18]1[CH2:26][CH2:21][CH:16]([NH:17][C:48]([C:45]2[NH:46][CH:47]=[C:43]([C:41]([C:40]3[C:36]([C:31]4[CH:32]=[CH:33][C:34]([F:35])=[C:29]([F:28])[CH:30]=4)=[N:37][O:38][C:39]=3[CH3:54])=[O:42])[CH:44]=2)=[O:53])[CH2:15][CH2:19]1

Participants

3

Reactant 2

HCID 57682986HCID 57682986, compound2×HCID 57683183HCID 57683183, compound

Product 1

HCID 16071485HCID 16071485, compound

Procedure

According to the procedure described for the synthesis of 4-(5-methyl-3-(4-fluorophenyl)-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid (cyclopropylmethyl)-amide (example 229, step 2), the title compound has been synthesized from 4-[3-(3,4-difluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-2-trichloroacetyl-1H-pyrrole (intermediate 19) and tetrahydro-pyran-4-yl amine(commercially available) in 41.5 yield. (m/e): 416.1 (MH+; 100%).

Sources & evidence

ORD record
ord-46ca539585bf4d1d89d7f3e0890f5e46
Source dataset
uspto-grants-2009_05
Patent number
US07538132B2

Reaction notes

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