Cyclopentylamine → HCID 16071598, compound

HRID 494328Notes

Reaction equation

HRID 494328 reaction equation
C1(CNC(C2NC=C(C(C3[C:16]([C:21]4[CH:26]=[CH:25][C:24](F)=CC=4)=[N:17]OC=3C)=O)C=2)=O)CC1.[F:28][C:29]1[CH:30]=[C:31]([C:36]2[C:40]([C:41]([C:43]3[CH:44]=[C:45]([C:48](=[O:53])C(Cl)(Cl)Cl)[NH:46][CH:47]=3)=[O:42])=[C:39]([CH3:54])[O:38][N:37]=2)[CH:32]=[CH:33][C:34]=1[F:35].C1(N)CCCC1>>[CH:16]1([NH:17][C:48]([C:45]2[NH:46][CH:47]=[C:43]([C:41]([C:40]3[C:36]([C:31]4[CH:32]=[CH:33][C:34]([F:35])=[C:29]([F:28])[CH:30]=4)=[N:37][O:38][C:39]=3[CH3:54])=[O:42])[CH:44]=2)=[O:53])[CH2:21][CH2:26][CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 2906CyclopentylamineHCID 57682986HCID 57682986, compound2×HCID 57683183HCID 57683183, compound

Product 1

HCID 16071598HCID 16071598, compound

Procedure

According to the procedure described for the synthesis of 4-(5-methyl-3-(4-fluorophenyl)-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid (cyclopropylmethyl)-amide (example 229, step 2), the title compound has been synthesized from 4-[3-(3,4-difluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-2-trichloroacetyl-1H-pyrrole (intermediate 19) and cyclopentylamine (commercially available) in 38.1 yield. (m/e): 400.1 (MH+; 100%).

Sources & evidence

ORD record
ord-bd2dd82594f74b089eb76545c04ae0e7
Source dataset
uspto-grants-2009_05
Patent number
US07538132B2

Reaction notes

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