HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 494361Generated: October 30, 2026
Sodium Hydroxide → HCID 22596780, compound
https://huagongshe.com/reaction/494361
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-ethoxy-1-[[2′-(methoxycarbonyl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate | HCID 15654679 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22596780 | HCID 22596780 | 83% |
Reaction Steps
To a solution of methyl 2-ethoxy-1-[(2′-methoxycarbonylbiphenyl-4-yl)methyl]benzimidazole-7-carboxylate (0.7 g) in methanol (10 ml) was added 1N NaOH (5 ml) and the mixture was stirred at 80° C. for 3 hours. After evaporation of the methanol, the aqueous residue was neutralized with 1N hydrochloric acid to give crystals. The crystals were recrystallized from methanol-chloroform to afford colorless crystals (0.54 g, 83%), m.p. 213-215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07538133B2 |
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| Source dataset | uspto-grants-2009_05 |
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| ORD ID | ord-18f5aeb088a348a78e64866102d1356c |
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| Source note | uspto-grants-2009_05 |
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