Thionyl Chloride → HCID 59804979, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of thionyl chloride (3.0 mL) and 2 drops of DMF stirring under nitrogen at 0° C. is added the title B compound, 4-(5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy)-benzenesulfonic acid sodium salt (1.1 g, 2.53 mmol) in one portion. The resulting suspension is stirred at 0° C. for 10 min. The ice bath is removed and the suspension is stirred at RT for 3 h. The solution is concentrated and the resulting residue is azeotrophed twice with toluene. The residue is taken up into DCM, filtered and evaporated at reduced pressure to give 4-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-benzenesulfonic acid chloride as an oil. It is used as such without any additional purification.

Provenance & Evidence