HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 3-Ethoxycarbonyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride | HCID 11066000 | — |
| Reactant | 4-Amino-3-ethoxycarbonylphenylacetic acid | HCID 23033226 | — |
| Product | 3-Ethoxycarbonyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenylacetic acid | HCID 57683225 | 58.6% |
Reaction Steps
The 4-amino-3-ethoxycarbonylphenylacetic acid (1.51 g) obtained in Example 9-4d) and 4′-trifluoromethylbiphenyl-2-carboxylic acid chloride (1.99 g) were subjected to reactions similar to those in Example 7a) with the proviso that sodium bicarbonate was used as a base, thereby the title compound (1.87 g) was given as a pale yellow amorphous powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07538140B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-fb2b296aa2754abe931bcb572cfd87e1 |
| Source note | uspto-grants-2009_05 |