HRID494413

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22236963

Diethyl (hydroxymethyl)(phenyl)propanedioate

C14H18O5

结构：CCOC(=O)c1cc(CC(=O)O)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1

HCID57683225

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cc(CC(=O)OCC(C(=O)OCC)(C(=O)OCC)c2ccccc2)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1

HCID57503494

未命名化合物

收率 64.5%

PROCEDURE

实验过程

The 3-ethoxycarbonyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenylacetic acid (0.532 g) obtained in Example 9-4e) and the 2-hydroxymethyl-2-phenylmalonic acid diethyl ester (1.04 g) obtained in Example 1-2a) were treated in a similar manner to Example 1g) to give the title compound (0.524 g) (see Table 59).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c45814699f09421f9359105c57a1f174
来源数据集: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07538140B2
来源说明: uspto-grants-2009_05

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]([CH2:31][C:32]([OH:34])=[O:33])[CH:9]=[CH:10][C:11]=1[NH:12][C:13]([C:15]1[C:16]([C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=2)=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:14])=[O:5])[CH3:2].[CH2:35]([O:37][C:38](=[O:53])[C:39]([CH2:51]O)([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:40]([O:42][CH2:43][CH3:44])=[O:41])[CH3:36]>>[CH2:43]([O:42][C:40](=[O:41])[C:39]([CH2:51][O:33][C:32](=[O:34])[CH2:31][C:8]1[CH:9]=[CH:10][C:11]([NH:12][C:13]([C:15]2[C:16]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:29])([F:28])[F:30])=[CH:23][CH:22]=3)=[CH:17][CH:18]=[CH:19][CH:20]=2)=[O:14])=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=1)([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:38]([O:37][CH2:35][CH3:36])=[O:53])[CH3:44]