Diethyl 2-(hydroxymethyl)-2-phenylmalonate → 2-(2-{3-Ethoxycarbonyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetoxymethyl)-2-phenylmalonic acid diethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]([CH2:31][C:32]([OH:34])=[O:33])[CH:9]=[CH:10][C:11]=1[NH:12][C:13]([C:15]1[C:16]([C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=2)=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:14])=[O:5])[CH3:2].[CH2:35]([O:37][C:38](=[O:53])[C:39]([CH2:51]O)([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:40]([O:42][CH2:43][CH3:44])=[O:41])[CH3:36]>>[CH2:43]([O:42][C:40](=[O:41])[C:39]([CH2:51][O:33][C:32](=[O:34])[CH2:31][C:8]1[CH:9]=[CH:10][C:11]([NH:12][C:13]([C:15]2[C:16]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:29])([F:28])[F:30])=[CH:23][CH:22]=3)=[CH:17][CH:18]=[CH:19][CH:20]=2)=[O:14])=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=1)([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:38]([O:37][CH2:35][CH3:36])=[O:53])[CH3:44]Participants
3
Reactant 2
Product 1
Procedure
The 3-ethoxycarbonyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenylacetic acid (0.532 g) obtained in Example 9-4e) and the 2-hydroxymethyl-2-phenylmalonic acid diethyl ester (1.04 g) obtained in Example 1-2a) were treated in a similar manner to Example 1g) to give the title compound (0.524 g) (see Table 59).
Sources & evidence
- ORD record
- ord-c45814699f09421f9359105c57a1f174
- Source dataset
- uspto-grants-2009_05
- Patent number
- US07538140B2
Reaction notes
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