反应详情

2,2′-(1,3-Phenylene)diacetic acid (10.0 g, 51 mmol) was dissolved in ethanol (100 mL) and the solution treated dropwise with catalytic acetyl chloride (2.5 mL). The reaction mixture was stirred at reflux for 18 hours before being allowed to cool and concentrated under reduced pressure. The residue was taken up in ethyl acetate (100 mL) and washed with sodium bicarbonate solution (3×50 mL) and brine (3×50 mL). The organic phase was dried over magnesium sulphate and concentrated under reduced pressure. The residue was triturated with pentane to yield the title product, 11.8 g.

1. temperatureat reflux for 18 hours
2. temperatureto cool
3. concentrationconcentrated under reduced pressure
4. washwashed with sodium bicarbonate solution (3×50 mL) and brine (3×50 mL)
5. dry with materialThe organic phase was dried over magnesium sulphate
6. concentrationconcentrated under reduced pressure
7. customThe residue was triturated with pentane