Dimethylformamide → 2-Phenyl-2-propylpentanoyl chloride

Participants

Reaction Conditions

Reaction Steps

A suspension of the product of Example 1C (4.13 g, 18.77 mmol) and N,N-dimethylformamide (1.45 mL, 18.77 mmol) in hexanes (700 mL) was treated with oxalyl chloride (4.91 mL, 56.31 mmol) and stirred at 25° C. for 2 hours. The mixture was treated with Celite®, and then filtered through a pad of Celite®. The filtrate was concentrated in vacuo to afford the title compound which was used directly in the next procedure.

Provenance & Evidence