反应详情

温度

25 °C

A suspension of the compound of Example 2F (110 mg, 0.21 mmol) in 1:1:1 tetrahydrofuran-ethyl acetate-methanol (20 mL) was treated with 10% palladium on carbon (30 mg) and stirred at 25° C. under hydrogen atmosphere for 18 hours. The mixture was filtered through Celite® and the filtrate concentrated in vacuo to afford the title compound (86 mg, 94%). 1H NMR (300 MHz, DMSO-d6): δ 13.87 (m, 1 H), 10.33 (s, 2 H), 8.15 (d, J=7.72 Hz, 1 H), 7.72 (m, 2 H), 7.52 (m, 2 H), 7.16 (m, 2 H), 2.15 (m, 2 H), 1.97 (m, J=11.77 Hz, 2H), 0.89 (m, 2 H), 0.60 (m, 8 H).

1. filtrationThe mixture was filtered through Celite®
2. concentrationthe filtrate concentrated in vacuo