Diethyl 2-(2-phenyl-2-propylpentanoyl)malonate → Methyl 1-hydroxy-4,4-diisopentyl-3-oxo-3,4-dihydro-2-naphthalenecarboxylate

HRID 494462Notes

Reaction equation

HRID 494462 reaction equation
[CH2:1]([C:6]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([CH2:18][CH2:19][CH:20]([CH3:22])[CH3:21])[C:7]([CH:9]([C:14]([O:16]C)=O)[C:10]([O:12][CH3:13])=[O:11])=[O:8])[CH2:2][CH:3]([CH3:5])[CH3:4].C1(C(CCC)(CCC)C(C(C(OCC)=O)C(OCC)=O)=O)C=CC=CC=1>>[OH:16][C:14]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:6]([CH2:18][CH2:19][CH:20]([CH3:21])[CH3:22])([CH2:1][CH2:2][CH:3]([CH3:5])[CH3:4])[C:7](=[O:8])[C:9]=1[C:10]([O:12][CH3:13])=[O:11]

Participants

3

Reactant 2

HCID 11552281Diethyl 2-(2-phenyl-2-propylpentanoyl)malonateHCID 69270654Dimethyl 2-(2-isopentyl-5-methyl-2-phenylhexanoyl)malonate

Product 1

HCID 68874215Methyl 1-hydroxy-4,4-diisopentyl-3-oxo-3,4-dihydro-2-naphthalenecarboxylate

Procedure

The title compound was prepared according to the procedure of Example 1F, substituting the product of Example 6E for the product of Example 1E. 1H NMR (300 MHz, CDCl3): δ 15.02 (d, J=4.04 Hz, 1 H), 8.21 (m, 1 H), 7.61 (m, 1 H), 7.41 (m, 2 H), 3.99 (s, 3H), 2.26 (m, 2 H), 1.92 (m, 2 H), 1.30 (m, 2 H), 0.79 (m, 14 H), 0.47 (m, 2 H).

Sources & evidence

ORD record
ord-1d991ac1ba364dfe9029476233132d3d
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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