3-[7-(benzyloxy)-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl]-4-hydroxy-1,1-dipropyl-2(1H)-naphthalenone → 4-hydroxy-3-(7-hydroxy-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,1-diisopentyl-2(1H)-naphthalenone

HRID 494464Notes

Reaction equation

HRID 494464 reaction equation
C([O:8][C:9]1[CH:42]=[CH:41][C:12]2[NH:13][C:14]([C:19]3[C:20](=[O:40])[C:21]([CH2:35][CH2:36][CH:37]([CH3:39])[CH3:38])([CH2:30][CH2:31][CH:32]([CH3:34])[CH3:33])[C:22]4[C:27]([C:28]=3[OH:29])=[CH:26][CH:25]=[CH:24][CH:23]=4)=[N:15][S:16](=[O:18])(=[O:17])[C:11]=2[CH:10]=1)C1C=CC=CC=1.C(OC1C=CC2NC(C3C(=O)C(CCC)(CCC)C4C(C=3O)=CC=CC=4)=NS(=O)(=O)C=2C=1)C1C=CC=CC=1>>[OH:29][C:28]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([CH2:35][CH2:36][CH:37]([CH3:39])[CH3:38])([CH2:30][CH2:31][CH:32]([CH3:34])[CH3:33])[C:20](=[O:40])[C:19]=1[C:14]1[NH:13][C:12]2[CH:41]=[CH:42][C:9]([OH:8])=[CH:10][C:11]=2[S:16](=[O:17])(=[O:18])[N:15]=1

Participants

3

Reactant 2

HCID 1363756003-[7-(benzyloxy)-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl]-4-hydroxy-1,1-dipropyl-2(1H)-naphthalenoneHCID 1363756013-[7-(benzyloxy)-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl]-4-hydroxy-1,1-diisopentyl-2(1H)-naphthalenone

Product 1

HCID 1354951934-hydroxy-3-(7-hydroxy-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,1-diisopentyl-2(1H)-naphthalenone

Procedure

The title compound was prepared by the procedure of Example 2G, substituting the product of Example 7B for the product of Example 2F. 1H NMR (300 MHz, DMSO-d6): δ 13.69 (s, 1 H), 10.42 (s, 1 H), 8.17 (d, J=7.72 Hz, 1 H), 7.77 (m, 1 H), 7.56 (m, 3 H), 7.19 (m, 2 H), 2.12 (m, 4 H), 1.29 (m, 2 H), 0.75 (m, 14 H), 0.38 (m, 2 H).

Sources & evidence

ORD record
ord-ed1b0f6985ba425b8532905307b7d1d0
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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