3-[7-(benzyloxy)-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl]-4-hydroxy-1,1-dipropyl-2(1H)-naphthalenone → HCID 136384895, compound

HRID 494479Notes

Reaction equation

HRID 494479 reaction equation
C([O:8][C:9]1[CH:39]=[CH:38][C:12]2[NH:13][C:14]([C:19]3[C:20](=[O:37])[C:21]([CH2:34][CH2:35][CH3:36])([CH2:31][CH2:32][CH3:33])[C:22]4[C:27]([C:28]=3[OH:29])=[CH:26][C:25]([F:30])=[CH:24][CH:23]=4)=[N:15][S:16](=[O:18])(=[O:17])[C:11]=2[CH:10]=1)C1C=CC=CC=1.C(OC1C=CC2NC(C3C(=O)C(CCC)(CCC)C4C(C=3O)=CC=CC=4)=NS(=O)(=O)C=2C=1)C1C=CC=CC=1>>[F:30][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[C:21]([CH2:34][CH2:35][CH3:36])([CH2:31][CH2:32][CH3:33])[C:20](=[O:37])[C:19]([C:14]1[NH:13][C:12]3[CH:38]=[CH:39][C:9]([OH:8])=[CH:10][C:11]=3[S:16](=[O:17])(=[O:18])[N:15]=1)=[C:28]2[OH:29]

Participants

3

Reactant 2

HCID 1363756003-[7-(benzyloxy)-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl]-4-hydroxy-1,1-dipropyl-2(1H)-naphthalenoneHCID 136403778HCID 136403778, compound

Product 1

HCID 136384895HCID 136384895, compound

Procedure

The title compound was prepared according to the procedure of Example 2G, substituting the compound of Example 15A for the compound of Example 2F. 1H NMR (300 MHz, DMSO-d6): δ 0.57 (m, 2 H) 0.68 (m, 6 H) 0.89 (m, 2 H) 2.01 (dd, J=12.13, 8.82 Hz, 2H) 2.17 (m, 2 H) 7.18 (m, 2 H) 7.62 (m, 2 H) 7.83 (m, 2 H) 10.41 (s, 1 H) 13.46 (s, 1 H).

Sources & evidence

ORD record
ord-fa5ad730f38842d9ba1d4ea27f99eeb5
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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