HRID494485

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCCC1(CCC)C(=O)C(C2=NS(=O)(=O)c3cc(NS(N)(=O)=O)ccc3N2)=C(O)c2cc(F)ccc21

HCID136337523

未命名化合物

PRODUCTS

生成物

结构：CCCC1(CCC)C(=O)C(C2=NS(=O)(=O)c3cc(NS(N)(=O)=O)ccc3N2)=C([O-])c2cc(F)ccc21.[Na+]

HCID68874514

未命名化合物

收率 94.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of Example 17E (13 mg) was dissolved in acetonitrile (1 mL) and treated with sodium hydroxide solution (1.0 N, 24.3 μL, 0.0243 mmol). After stirring for 30 min, the solution was frozen and lyophilized to afford the title compound as a fluffy grey solid (12.8 mg, 55% overall). 1H NMR (300 MHz, DMSO-d6): δ 0.65 (m, 8 H) 0.86 (d, J=2.94 Hz, 2 H) 1.65 (d, J=3.68 Hz, 2 H) 2.05 (m, 2 H) 7.43 (m, 6 H) 9.58 (s, 1 H) 15.21 (s, 1 H).

WORKUP

后处理

temperaturethe solution was frozen

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d2b2079566584a5fae438dfe9aff5bb8
来源数据集: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07538105B2
来源说明: uspto-grants-2009_05

反应 SMILES

[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH2:34][CH2:35][CH3:36])([CH2:31][CH2:32][CH3:33])[C:7](=[O:30])[C:8]([C:13]3[NH:18][C:17]4[CH:19]=[CH:20][C:21]([NH:23][S:24]([NH2:27])(=[O:26])=[O:25])=[CH:22][C:16]=4[S:15](=[O:29])(=[O:28])[N:14]=3)=[C:9]2[OH:12])=[CH:4][CH:3]=1.[OH-].[Na+:38]>C(#N)C>[NH2:27][S:24]([NH:23][C:21]1[CH:20]=[CH:19][C:17]2[NH:18][C:13]([C:8]3[C:7](=[O:30])[C:6]([CH2:31][CH2:32][CH3:33])([CH2:34][CH2:35][CH3:36])[C:5]4[C:10](=[CH:11][C:2]([F:1])=[CH:3][CH:4]=4)[C:9]=3[O-:12])=[N:14][S:15](=[O:29])(=[O:28])[C:16]=2[CH:22]=1)(=[O:25])=[O:26].[Na+:38]