HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 494540Generated: October 30, 2026
2-Aminobenzenesulfonamide → 1-(5,5-Dimethylhexyl)-3-(1,1-dioxido-4h-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-methylnaphthalen-2(1h)-one
https://huagongshe.com/reaction/494540
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminobenzenesulfonamide | HCID 72894 | — |
| Reactant | 2-[Bis(methylthio)methylene]-4-(5,5-dimethylhexyl)-4-methylnaphthalene-1,3(2h,4h)-dione | HCID 11303866 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(5,5-Dimethylhexyl)-3-(1,1-dioxido-4h-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-methylnaphthalen-2(1h)-one | HCID 135481013 | 852.1% |
Reaction Steps
A solution of Example 35H (0.097 g, 0.249 mmol) and 2-amino-benzenesulfonamide (0.045 g, 0.262 mmol) in toluene (7 mL) was refluxed for 6 hours. The solution was cooled to 25° C. and concentrated in vacuo. The residue was chromatographed on silica gel eluting with hexane followed by 20% and 30% ethyl acetate in hexane to give the desired product (0.99 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07538105B2 |
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| Source dataset | uspto-grants-2009_05 |
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| ORD ID | ord-be379cd4ff9a4bae972b1caed13d7c88 |
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| Source note | uspto-grants-2009_05 |
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