Sodium Hydroxide → HCID 44456290, compound

HRID 494550Notes

Reaction equation

HRID 494550 reaction equation
[CH3:1][C:2]([CH3:38])([CH3:37])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]1([CH3:36])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([OH:17])=[C:9]([C:18]2[NH:23][C:22]3[CH:24]=[CH:25][C:26]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])=[CH:27][C:21]=3[S:20](=[O:34])(=[O:33])[N:19]=2)[C:8]1=[O:35].[OH-].[Na+:40]>O>[CH3:1][C:2]([CH3:38])([CH3:37])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]1([CH3:36])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([O-:17])=[C:9]([C:18]2[NH:23][C:22]3[CH:24]=[CH:25][C:26]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])=[CH:27][C:21]=3[S:20](=[O:34])(=[O:33])[N:19]=2)[C:8]1=[O:35].[Na+:40]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135430232HCID 135430232, compound

Product 1

HCID 44456290HCID 44456290, compoundYield 98.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 37C (0.302 g) in water (10 mL) was treated with 0.997N sodium hydroxide solution (0.545 mL, 0.540 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.308 g, 98%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.58 (m, 1 H) 0.73 (m, 9 H) 0.95 (m, 5 H) 1.38 (m, 3 H) 1.71 (m, 1H) 2.13 (m, 1 H) 2.94 (m, 3 H) 7.32 (m, 3 H) 7.46 (m, 3 H) 8.04 (m, 1 H) 9.88 (m, 1 H) 15.46 (m, 1 H). MS (ESI−) m/z 558 (M−H)−.

Sources & evidence

ORD record
ord-dec8f978646742e7be0ffeb4555ffc73
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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