Sodium Hydroxide → HCID 44456254, compound

HRID 494552Notes

Reaction equation

HRID 494552 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]2([CH3:39])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([OH:20])=[C:12]([C:21]3[NH:26][C:25]4[CH:27]=[CH:28][C:29]([NH:31][S:32]([CH3:35])(=[O:34])=[O:33])=[CH:30][C:24]=4[S:23](=[O:37])(=[O:36])[N:22]=3)[C:11]2=[O:38])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+:41]>O>[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]2([CH3:39])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([O-:20])=[C:12]([C:21]3[NH:26][C:25]4[CH:27]=[CH:28][C:29]([NH:31][S:32]([CH3:35])(=[O:34])=[O:33])=[CH:30][C:24]=4[S:23](=[O:36])(=[O:37])[N:22]=3)[C:11]2=[O:38])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Na+:41]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135451069HCID 135451069, compound

Product 1

HCID 44456254HCID 44456254, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 38C (0.339 g) in water (10 mL) was treated with 0.997N sodium hydroxide solution (0.595 mL, 0.593 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.334 g, 95%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.63 (m, 3 H) 0.98 (m, 8 H) 1.45 (m, 7 H) 1.68 (m, 1 H) 2.09 (m, 1H) 2.93 (m, 3 H) 7.30 (m, 3 H) 7.45 (m, 3 H) 8.05 (m, 1 H) 9.87 (m, 1 H) 15.45 (m, 1 H). MS (ESI−) m/z 570 (M−H)−.

Sources & evidence

ORD record
ord-62f56d4a196447df9e62ec06751a9332
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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