HCID 68875089, compound → HCID 68872386, compound

Participants

Reaction Steps

A solution of Example 55E (0.055 g, 0.174 mmol) in 4 mL of dioxane and 4 mL of 1N HCl was refluxed for 3 hours. The solution was cooled to room temperature, diluted with water and extracted with 3× ethyl acetate. The combined organic layers were dried over MgSO4, and concentrated in vacuo to yield the title compound (0.035 g, 83% yield) as an oil that solidifies on standing. 1H NMR (300 MHz, DMSO-d6): δ ppm 1.16 (m, 3H) 1.48 (s, 3H) 1.70 (m, 3H) 2.04 (m, 2H) 2.21 (m, 1H) 5.76 (m, 1H) 7.30 (m, 1H) 7.44 (m, 1H) 7.63 (m, 1H) 8.00 (d, J=8.09 Hz, 1H). MS (ESI+) m/z=243 (M+H)+.

Provenance & Evidence