Trifluoroacetic acid → HCID 135430175, compound

Participants

Reaction Steps

A solution of Example 55H (0.105 g, 0.195 mmol) in dichloromethane (2 mL) was treated with trifluoroacetic acid (2 mL) at room temperature for 1 hour. After concentrating in. vacuo, the resulting oil was partitioned between ethyl acetate and NaHCO3(aq,), the organic layer was removed and the bicarb layer extracted 3× with ethyl acetate. The combined organic layers were dried over MgSO4, filtered, and concentrated in. vacuo. to yield a solid that was used without further purification. 1H NMR (300 MHz, DMSO-d6): δ ppm 1.22 (m, 3H) 1.47 (m, 3H) 1.57 (s, 3H) 1.71 (m, 2H) 2.18 (m, 1H) 2.32 (m, 1H) 7.01 (m, 2H) 7.45 (d, J=8.46 Hz, 1H) 7.54 (t, J=7.17 Hz, 1H) 7.76 (m, 2H) 8.15 (d, J=7.72 Hz, 1H) 13.54 (m, 1H). MS (ESI+) m/z=438 (M+H)+.

Provenance & Evidence