HCID 137194537, compound → HCID 136384773, compound

Participants

Reaction Steps

A solution of Example 85 (56 mg, 0.086 mmol) in 7 mL of methanol was treated with 10% palladium on carbon (28 mg, 50 wt %) and placed under an atmosphere of hydrogen. The mixture was stirred at room temp for 5 h, filtered through a 0.45 □M syringe filter, and concentrated in vacuo to afford the desired product (35 mg, 79% yield). 1H NMR (300 MHz, DMSO-d6) δ ppm 0.56 (m, 2H) 0.67 (m, 6H) 0.87 (m, 2H) 1.96 (m, J=11.40, 11.40 Hz, 2H) 2.16 (m, 2H) 7.37 (s, 2H) 7.59 (m, 6H) 8.15 (d, J=7.72 Hz, 1H) 9.99 (s, 1H) 13.94 (s, 1H); (ESI+) m/z 519 (M+H)+ (ESI+) m/z 536 (M+NH4)+ (ESI+) m/z 541 (M+Na)+ (ESI+) m/z 1054 (2M+NH4)+ (ESI−) m/z 517 (M−H)− (ESI−) m/z 1035 (2M−H)−

Provenance & Evidence