Butyric Acid → HCID 45119351, compound

HRID 494611Notes

Reaction equation

HRID 494611 reaction equation
[C:1]([OH:6])(=O)[CH2:2][CH2:3][CH3:4].[Cl:7][S:8]([N:11]=C=O)(=[O:10])=[O:9]>C1C=CC=CC=1>[C:1]([NH:11][S:8]([Cl:7])(=[O:10])=[O:9])(=[O:6])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 264Butyric AcidHCID 70918Chlorosulfonyl isocyanate

Product 1

HCID 45119351HCID 45119351, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

n-Butanoic acid (0.881 g, 10 mmol) was added slowly dropwise to chlorosulfonyl isocyanate (1.42 g, 10 mmol), with ice/water bath cooling as required to maintain gentle gas evolution. After the addition was complete, the residue was taken up in benzene (10 mL) and the mixture concentrated in vacuo to provide the title compound (1.85 g, quantitative) as a crystalline, hygroscopic solid.

Workup

  1. temperaturecooling
  2. temperatureto maintain gentle gas evolution
  3. additionAfter the addition
  4. concentrationthe mixture concentrated in vacuo

Sources & evidence

ORD record
ord-1562149e15e2403ebd40c297a4cfd49c
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

Loading…