HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-(4-Methoxyphenyl)-2,5-dimethylhexanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 68870239 | HCID 68870239 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Methoxyphenyl)-2,5-dimethylhexanoyl chloride | HCID 87608862 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a cooled solution of Example 155C (8.52 g, 0.034 mol) in 200 mL anhydrous dichloromethane was added 2 N oxalyl chloride in dichloromethane (26 mL, 0.052 mol) and drops of dimethylforamide. The solution was stirred for 30 minutes at 0° C. and then room temperature for 2 hours. The solvent was removed under vacuum and the crude product used directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07538105B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-dfa8704dc64947c99d9344cacb87e7aa |
| Source note | uspto-grants-2009_05 |