HCID 58886641, compound → HCID 58886648, compound

Participants

Reaction Steps

8-Fluoro-7-(2-fluoro-4-vinyl-phenylamino)-imidazo[1,2-a]pyridine -6-carboxylic acid methyl ester (165 mg, 0.50 mmol) was suspended in ethanol (5mL), added 10% Pd/C (267 mg, 0.25 mmol) and placed under an atmosphere of H2. The reaction mixture was stirred vigorously at room temperature for 16 hours. The reaction mixture was filtered through CELITE, washed with ethanol and tetrahydrofuran and the filtrate concentrated to a yellow oil. Purification of the crude product by flash column chromatography (gradient of dichloromethane to 20:1 dichloromethane/methanol) provided the desired product (110 mg, 66%) as a dark yellow solid. MS ESI (+) m/z 332 (M+1) detected.

Provenance & Evidence