Hydrochloric Acid → HCID 21867008, compound

Participants

Reaction Steps

Sodium hydroxide (715 μL of a 1 M solution) was added to a solution of 7-(4-bromo-2-chlorophenylamino)-8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid ethyl ester (51a) (79 mg, 179 mmol) in 3:1 THF:water (4.5 mL). After 16 hours, the reaction mixture was poured into a separatory funnel, diluted with brine and acidified with 1 M HCl to about pH 2. The aqueous layer was extracted with 1:1 EtOAc/THF. The combined organic extracts were dried (Na2SO4) and concentrated and the residue (52a) was carried forward without further purification.

Provenance & Evidence