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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 494763Generated: October 30, 2026

Piperidine → 4-[2-(2-Piperidin-1-yl-ethyl)-benzofuran-5-yl]-benzonitrile

https://huagongshe.com/reaction/494763

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidineHCID 8082—
Reactant2-[5-(4-cyanophenyl)-1-benzofuran-2-yl]ethyl MethanesulfonateHCID 11393678—
Product4-[2-(2-Piperidin-1-yl-ethyl)-benzofuran-5-yl]-benzonitrileHCID 10471844—

Reaction Steps

The product from Example 1C and piperidine were processed as described in Example 1D to provide the titled compound. 1H NMR (300 MHz, CD3OD) δ 7.88 (m, 1H), 7.80 (m, 4H), 7.60 (m, 2H), 6.82 (s, 1H), 3.65 (m, 2H), 3.55 (m, 2H), 3.33 (m, 2H), 3.05 (m, 2H), 2.0 (m, 2H), 1.5-1.9 (m, 4H); MS (DCI) m/z 331 (M+H)+;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07538138B2
Source datasetuspto-grants-2009_05
ORD IDord-23434416c2654b0a83506746a51cbeaa
Source noteuspto-grants-2009_05