2-Methylpiperidine → 4-{2-[2-(2-Methyl-1-piperidinyl)ethyl]-1-benzofuran-5-yl}benzonitrile

HRID 494765Notes

Reaction equation

HRID 494765 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)=[CH:13][C:11]=2[CH:12]=1)(=O)=O.[CH3:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][NH:27]1>>[CH3:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][N:27]1[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)=[CH:13][C:11]=2[CH:12]=1

Participants

3

Reactant 2

HCID 79742-MethylpiperidineHCID 113936782-[5-(4-cyanophenyl)-1-benzofuran-2-yl]ethyl Methanesulfonate

Product 1

HCID 103601494-{2-[2-(2-Methyl-1-piperidinyl)ethyl]-1-benzofuran-5-yl}benzonitrile

Procedure

The product from Example 1C and 2-methylpiperidine were processed as described in Example 1D to provide the titled compound. 1H NMR (300 MHz, CD3OD) δ 7.88 (m, 1H), 7.80 (m, 4H), 7.60 (m, 2H), 6.82 (s, 1H), 3.1-3.8 (m, 7H), 1.6-2.1 (m, 6H), 1.45 (d, 3H, J=6 Hz); MS (DCI) m/z 345 (M+H)+;

Sources & evidence

ORD record
ord-6699be81bb304d848e660d2515d670c0
Source dataset
uspto-grants-2009_05
Patent number
US07538138B2

Reaction notes

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