Prolinol, (R)- → HCID 10382998, compound

HRID 494773Notes

Reaction equation

HRID 494773 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)=[CH:13][C:11]=2[CH:12]=1)(=O)=O.[NH:25]1[CH2:31][CH2:30][CH2:29][C@@H:26]1[CH2:27][OH:28]>>[OH:28][CH2:27][C@H:26]1[CH2:29][CH2:30][CH2:31][N:25]1[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)=[CH:13][C:11]=2[CH:12]=1

Participants

3

Reactant 2

HCID 2724541Prolinol, (R)-HCID 113936782-[5-(4-cyanophenyl)-1-benzofuran-2-yl]ethyl Methanesulfonate

Product 1

HCID 10382998HCID 10382998, compound

Procedure

The product from Example 1C and (D)-prolinol were processed as described in Example 1D to provide the titled compound. 1H NMR (300 MHz, CD3OD) δ 7.87 (m, 1H), 7.82 (m, 4H), 7.58 (m, 2H), 6.80 (s, 1H), 3.95 (m, 2H), 3.72 (m, 2H), 3.58 (m, 1H), 3.35-3.4 (m, 4H), 1.95-2.3 (m, 4H); MS (DCI) m/z 347 (M+H)+;

Sources & evidence

ORD record
ord-9577e4be492143f9b3af1e416df6cd7d
Source dataset
uspto-grants-2009_05
Patent number
US07538138B2

Reaction notes

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