Morpholine → 4'-(4-Morpholinylcarbonyl)[1,1'-biphenyl]-4-ol

関与物質

役割	名称	HCID	仕込み量
反応物	Morpholine	HCID 8083	—
反応物	Triethylamine	HCID 8471	—
反応物	4'-Hydroxy-4-biphenylcarboxylic acid	HCID 301556	—
反応物	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
溶媒	Dichloromethane	HCID 6344	—
生成物	4'-(4-Morpholinylcarbonyl)[1,1'-biphenyl]-4-ol	HCID 22274689	83.2%

反応手順

To a solution of 4-hydroxy-biphenyl-4′-carboxylic acid (5.35 g, 25.0 mmol), morpholine (2.39 g, 27.5 mmol) and triethylamine (3.5 mL, 25 mmol) in dichloromethane (100 mL) was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride. The mixture was stirred for 16 hours, diluted with aqueous NaH2PO4 and filtered. The solid was washed with 1:2 diethyl ether/water (100 mL) then with water (400 mL). The solid was dried in vacuo to give the titled compound (5.89 g, 83%). MS (DCI) m/z 284 (M+H)+;

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07538138B2
出典データセット	uspto-grants-2009_05
ORD ID	ord-3c4e521ae07245b9b70a018e38637a0e
出典メモ	uspto-grants-2009_05