Sodium Carbonate → HCID 22274686, compound

Participants

Reaction Steps

3′-Fluoro-4′-hydroxy-1,1′-biphenyl-4-carbonitrile (320 mg, 1.50 mmol) was dissolved into DMF (7 mL) and treated with N-iodosuccinimide (360 mg, 1.60 mmol). The solution was stirred at room temperature overnight. Then the mixture was poured into an aqueous mixture of Na2SO3 and Na2CO3, adjusted to pH 9 with aqueous potassium dihydrogen phosphate, and extracted with ether. The combined organic phases were dried (Na2SO4) and concentrated to provide the title compound as a pinkish solid (100% yield). MS (ESI APCI negative ion detection) m/z 338 (M−H)−.

Provenance & Evidence