Ethyl chloroformate → 6-[4-(Allyl-methyl-amino)-but-2-enyloxy]-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([N:4]([CH3:20])[CH2:5][CH:6]=[CH:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH2:15][CH2:14][CH2:13]2)[CH:2]=[CH2:3].[CH2:21]([O:23][C:24](Cl)=[O:25])[CH3:22]>>[CH2:21]([O:23][C:24]([N:16]1[C:17]2[C:12](=[CH:11][C:10]([O:9][CH2:8][CH:7]=[CH:6][CH2:5][N:4]([CH2:1][CH:2]=[CH2:3])[CH3:20])=[CH:19][CH:18]=2)[CH2:13][CH2:14][CH2:15]1)=[O:25])[CH3:22]Participants
3
Procedure
In analogy to example 3.9, Allyl-methyl-[4-(1,2,3,4-tetrahydro-quinolin-6-yloxy)-but-2-enyl]-amine and ethylchloroformate were converted to yield 6-[4-(Allyl-methyl-amino)-but-2-enyloxy]-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester as brown oil, MS: 345 (MH+).
Sources & evidence
- ORD record
- ord-3a1baf2ff72344cf80ac1b13c9adfba5
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06706751B2
Reaction notes
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