(S)-2-methylpyrrolidine hydrobromide → 4-{[6-(2-{2-[(2S)-methylpyrrolidinyl]ethyl}-1-benzofuran-5-yl)-3-pyridinyl]carbonyl}morpholine

HRID 494894Notes

Reaction equation

HRID 494894 reaction equation
Br.[CH3:2][C@H:3]1[CH2:7][CH2:6][CH2:5][NH:4]1.CS(O[CH2:13][CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([N:32]4[CH2:37][CH2:36][O:35][CH2:34][CH2:33]4)=[O:31])=[CH:26][N:25]=3)=[CH:20][C:18]=2[CH:19]=1)(=O)=O>>[CH3:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:13][CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][C:21]([C:24]3[N:25]=[CH:26][C:27]([C:30]([N:32]4[CH2:37][CH2:36][O:35][CH2:34][CH2:33]4)=[O:31])=[CH:28][CH:29]=3)=[CH:20][C:18]=2[CH:19]=1

Participants

3

Reactant 2

HCID 20779371(S)-2-methylpyrrolidine hydrobromideHCID 222745562-{5-[5-(4-Morpholinylcarbonyl)-2-pyridinyl]-1-benzofuran-2-yl}ethyl methanesulfonate

Product 1

HCID 675339884-{[6-(2-{2-[(2S)-methylpyrrolidinyl]ethyl}-1-benzofuran-5-yl)-3-pyridinyl]carbonyl}morpholine

Procedure

(2S)-2-Methylpyrrolidine hydrobromide and the product from Example 44E (2-{5-[4-(4-morpholinylcarbonyl)phenyl]-1-benzofuran-2-yl}ethyl methanesulfonate) are processed as described in Example 1D to provide the titled compound.

Sources & evidence

ORD record
ord-a193082c8e0f46eab2c02e3ad9ea0abe
Source dataset
uspto-grants-2009_05
Patent number
US07538138B2

Reaction notes

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