(S)-2-methylpyrrolidine hydrobromide → 3-(2-{2-[(2S)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile

HRID 494895Notes

Reaction equation

HRID 494895 reaction equation
Br.[CH3:2][C@H:3]1[CH2:7][CH2:6][CH2:5][NH:4]1.CS(O[CH2:13][CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#[N:31])[CH:25]=3)=[CH:20][C:18]=2[CH:19]=1)(=O)=O>>[CH3:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:13][CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][C:21]([C:24]3[CH:25]=[C:26]([CH:27]=[CH:28][CH:29]=3)[C:30]#[N:31])=[CH:20][C:18]=2[CH:19]=1

Participants

3

Reactant 2

HCID 20779371(S)-2-methylpyrrolidine hydrobromideHCID 222744452-[5-(3-Cyanophenyl)-1-benzofuran-2-yl]ethyl methanesulfonate

Product 1

HCID 675340423-(2-{2-[(2S)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile

Procedure

(2S)-2-Methylpyrrolidine hydrobromide and the product from Example 112D are processed as described in Example 1D to provide the titled compound.

Sources & evidence

ORD record
ord-168b1975387a4f9fa3ae78534a6aff6a
Source dataset
uspto-grants-2009_05
Patent number
US07538138B2

Reaction notes

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