Water → HCID 57682926, compound

Participants

Reaction Steps

1.44 g of 4-allyl-5-hydroxy-2-methylbenzoxazole was dissolved in 5 ml of N,N-dimethylformamide and 5 ml of acetonitrile. Thereafter, 1.05 g of potassium carbonate and 0.55 ml of methyl iodide were successively added to the reaction solution. Approximately 16 hours later, water and ethyl acetate were added to the reaction solution, so as to separate an organic layer. The obtained organic layer was washed with a saturated sodium chloride solution and then dried over anhydrous magnesium sulfate. After removing the drying agent by filtration, the organic layer was concentrated under a reduced pressure, and the residue was then purified by silica gel column chromatography (hexane/ethyl acetate), so as to obtain 1.26 g of the subject compound.

Provenance & Evidence