Sodium Bicarbonate → HCID 57682777, compound

Participants

Reaction Steps

52 mg of 1-(1-(2-(7-methoxy-4-oxo-4H-chromen-8-yl)ethyl)piperidin-4-yl)-1H-indole-6-carboxamide was dissolved in 6 ml of methanol-tetrahydrofuran (1:1). Thereafter, 5 mg of sodium borohydride was added to the reaction solution while cooling on ice. The obtained mixture was then stirred at room temperature for 2 hours. Thereafter, 5 mg of sodium borohydride was added to the reaction solution, and further, 5 mg each of sodium borohydride was added thereto 2 hours and 4 hours later. Thereafter, the reaction solution was stirred at the same temperature overnight. A saturated sodium bicarbonate aqueous solution was added to the reaction solution, followed by extraction with chloroform. The extract was dried over magnesium sulfate and then concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate-methanol), so as to obtain 30 mg of the subject compound.

Provenance & Evidence