HCID 57682848, compound → HCID 57682931, compound

Participants

Reaction Steps

42 mg of 1-(1-(2-(7-methoxy-4-oxo-4H-chromen-8-yl)ethyl)piperidin-4-yl)-1H-indole-6-carboxamide was dissolved in 3 ml of methanol. Thereafter, 15 mg of 10% palladium carbon was added to the reaction solution. The obtained mixture was then stirred at room temperature for 15 hours under hydrogen atmosphere. Thereafter, 15 mg of 10% palladium carbon was further added to the reaction solution. The obtained mixture was then stirred at the same temperature for 4 hours. Thereafter, palladium carbon was removed by filtration, and the filtrate was concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate), so as to obtain 20 mg of the subject compound.

Provenance & Evidence