反应详情

3 ml of acetic anhydride and 3 ml of pyridine were added to 251 mg of 7-(2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, and the obtained mixture was then stirred at room temperature for 90 minutes. The reaction solution was concentrated under a reduced pressure. The residue was diluted with ethyl acetate and then washed with water and a saturated sodium chloride aqueous solution. The organic layer was dried over magnesium sulfate and then concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (hexane-ethyl acetate) and then by silica gel column chromatography (ethyl acetate-methanol), so as to obtain 162 mg of the subject compound.

1. concentrationThe reaction solution was concentrated under a reduced pressure
2. additionThe residue was diluted with ethyl acetate
3. washwashed with water
4. dry with materialThe organic layer was dried over magnesium sulfate
5. concentrationconcentrated under a reduced pressure
6. customThe residue was purified by NH silica gel column chromatography (hexane-ethyl acetate)